Pharmacological Intervention in the Aging Process by H. George Mandel (auth.), Jay Roberts, Richard C. Adelman,

By H. George Mandel (auth.), Jay Roberts, Richard C. Adelman, Vincent J. Cristofalo (eds.)

In the approximately 3 years that experience elapsed in view that our first Philadelphia Symposium on getting older, our actions and interactions have multiplied. We spent no small period of time discussing the choice of a well timed subject for our subsequent symposium. For the 1st symposium, various subject matters in terms of the learn of getting older, starting from phenomena on the mobile point to phenomena in affliction states, have been chosen for attention. For the current symposium, we notion it more suitable to be aware of one region merely, so as to summarize on hand info, realize what shortcomings exist, and recommend new instructions for learn. The paucity of in­ formation on pharmacological reviews in getting older and the compelling necessity for those stories made it transparent to us that the time was once acceptable for a assessment of this material. The technique was once to contemplate themes relating to the results of getting older at the simple homes of drug motion and at the effectiveness of gear utilized in the remedy of illnesses in numerous organ structures. additionally, it was once felt that by means of contemplating many of the pharmacological equipment of intervention within the getting older procedure, larger perception into the character of getting older might emerge. For the symposium, we introduced jointly thirteen notable staff within the box of pharmacology to debate the chosen subject matters. we think that the chapters can be informative to staff in pharmacology and in biomedical disciplines often, in addition to offer a company starting place for destiny paintings during this interesting area.

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There is an absolute loss of this histone and not merely a cessation of synthesis of the protein. Table 1 illustrates this finding. Hx represents about 6% of the main H1 histone and less than 1 of the total histones of the cell. In the presence of an active glucocorticoid, there is no change in the H1 histone, but ~ starts declining and by 3 hr is present at about half the amount originally present. This Hx histone has been purified on preparative columns; its molecular weight is about 20,100 (versus 21,500 for H1 of mouse fibroblasts), and its amino acid composition is very similar to H1 .

DRUG-RECEPTOR INTERACTIONS 41 of these subclasses. Indeed, a developmenta l pattern has been described in several studies, and it is known that rapidly dividing cells have r:latively small amounts of a satellite H1 histone known as Hla• wh1le cells that have ceased dividing have appreciable amounts of this protein (18, 19). Thus, there is a basis for suggesting a regulatory role for satellite H1 histones. RECEPTORS AND THE AGING PROCESS There is a limited amount of information available on steroid receptors in developmenta l systems and somewhat less on alterations of receptor content in the aging process.

R. Gillette, ed), p. 378-400, Springer-Verlag, Berlin Heidelberg, New York, 1971. Dutton, G. : Glucuronide-forming enzymes, in Handbuch der experimentellen pharmakologie, Vol. XXVIII, Concepts in biochemical pharmacology, FarL 2 (B. n. Tirodi~ ~nd J. R. ), p. 378-400, Springer-Verlag, Berlin, Heidelberg, New York, 1971. , Jerina, D. M. and Daly, J. : Substrate specificity of hepatic epoxide hydrase in microsomes and in a purified preparation: evidence for homologous enzymes, Arch. Biochem. Biophys.

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