Pathogenic yeasts by David A. Fitzpatrick, Geraldine Butler (auth.), Ruth Ashbee,

By David A. Fitzpatrick, Geraldine Butler (auth.), Ruth Ashbee, Elaine M. Bignell (eds.)

Mycological experiences of yeasts are coming into a brand new part, with the sequencing of a number of fungal genomes informing our knowing in their skill to reason ailment and engage with the host. while, the continued use of conventional tools in lots of scientific mycology laboratories keeps to supply details for the analysis and remedy of sufferers. This quantity stories quite a few elements of pathogenic yeasts and what's identified approximately their molecular and mobile biology and virulence, as well as taking a look at scientific and laboratory findings. As each one bankruptcy is written by way of a number one professional within the box, this e-book summarizes in a single quantity a lot of the most recent learn on numerous pathogenic yeasts, together with Candida, Cryptococcus, Malassezia and yeasts of rising value. the significance of laboratory prognosis, antifungal susceptibility trying out, antifungal resistance and yeast ailments in animals are reviewed.

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Pathogenic yeasts

Mycological reviews of yeasts are coming into a brand new section, with the sequencing of a number of fungal genomes informing our realizing in their skill to reason ailment and have interaction with the host. while, the continued use of conventional tools in lots of medical mycology laboratories maintains to supply details for the prognosis and remedy of sufferers.

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2005). Interestingly, this clade of C. dubliniensis isolates were found to be resistant to 5FC, although the mechanism is so far unknown. David Soll and colleagues have also developed fingerprinting probes for C. glabrata (Lockhart et al. 1997) C. tropicalis (Joly et al. 1996) and C. parapsilosis (Enger et al. 2001). 2 Multi-Locus Sequence Typing (MLST) of C. albicans In recent years, DNA sequencing has become more affordable and widely available, which has made typing methods that involve characterising DNA sequence polymorphisms more accessible.

2002). C. glabrata has a high propensity to develop resistance to azole anti-fungals, whereas C. krusei is inherently resistant to fluconazole (Fidel et al. 1999; Samaranayake and Samaranayake 1994). However, increased reporting of infection caused by non-C. albicans Candida species may also be the result of recent improvements in isolation and identification methods for Candida species. The distribution of species recovered from blood culture also changes with geography, particularly with regard to C.

J Clin Microbiol 43:4026–4036 Banerjee SN, Emori TG, Culver DH, Gaynes RP, Jarvis WR, Horan T, Edwards JR, Tolson J, Henderson T, Martone WJ (1991) Secular trends in the epidemiology of nosocomial primary bloodstream infections in the United States, 1980–1989. Am J Med 91(Suppl. 3B):86S–89S Bougnoux ME, Morand S, d’Enfert C (2002) Usefulness of multilocus sequence typing for characterization of clinical isolates of Candida albicans. J Clin Microbiol 40:1290–1297 Bougnoux ME, Aanensen DM, Morand S, Theraud M, Spratt BG, d’Enfert C (2004) Multilocus sequence typing of Candida albicans: strategies, data exchange and applications.

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