By Dr. phil. nat., Dr. med. Jürgen Fuchs (auth.)
Dermatology is a fancy and difficult global of itching bumps, pim ples, and rashes. The multitude of clinically specific dermis ailments, their usually unresolved pathogenesis, and the exponentially in creasing quantity of clinical details upload to the confusion approximately epidermis illnesses. the nice occurrence of epidermis illnesses makes them an pressing precedence for in depth learn attempt, and even though many scientists and educational clinicians are vigorously attempting to discover we're merely on the very breaking point of realizing the etiol their secrets and techniques, ogy of such a lot dermatoses. the main mechanisms of basic organ pathology (physical, chemical, microbial, ischemic, degenerative, and neoplastic disturb ances) are believed to be particularly good understood. unlike dermis pathomorphology, even though little is understood concerning the bio chemistry and body structure of dermatoses. the trouble in less than status pores and skin ailments might be conquer in part by way of discovering biome dical simplifications, and the concept that of "oxidative damage in dermatopathology" is simply one of these simplification. it's going to, in fact, continuously be saved in brain that no unmarried mechanism by myself can clarify the pathogenesis of a ailment and that there's a risk of over having a look different vital organic determinants.
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Additional info for Oxidative Injury in Dermatopathology
The epidermal content of lipid peroxidation products in influenced by the cell turnover rate: A high mitotic activity is correlated with low levels of lipid peroxidation (Logani et al. 1982). Targets of Reactive Oxidants in Skin 35 Antimicrobial Activity. The physiological presence of lipid peroxidation products in the outermost skin layers (stratum corneum) may be a regulatory device in the control of antimicrobial defense. The bactericidal activity ofUV-irradiated fats was discovered about 6 decades ago (Harris et a1.
Cytochrome P-450 isoenzymes in the epidermis of rats are markedly induced by nitropyrenes (Asokan et al. 1985) and polycyclic aromatic hydrocarbons (Thompson and Slaga 1976), both important carcinogenic environmental pollutants. It must be pointed out, however, that isolated microsomes are artifacts, and due to the isolation procedure components of the electron transport chain may by dearranged, resulting in an increased release of free radicals. The true free radical formation in the endoplasmic reticulum in vivo may be significantly lower than in vitro.
The underlying subcutis is mainly built up of fat cells. Dermis and subcutis also contain some endothelial cells (blood and lymph vessels). During inflammatory reactions, skin can be significantly infiltrated with leukocytes. Reactive oxidant mediated diseases can be categorized by the major site of pathologically increased generation of reactive species. Biological sources of reactive oxidants in skin can be endogenous or exogenous. Exogenous sources comprise redox cycling xenobiotics and electromagnetic irradiation.