Inhaler Devices. Fundamentals, Design and Drug Delivery by Polina Prokopovich

By Polina Prokopovich

Given their direct impression at the health and wellbeing and caliber of existence for hundreds of thousands, inhalers signify a tremendous turning element within the historical past of contemporary medication. Inhaler units: basics, layout and drug supply offers readers with an creation to the basics of inhaler know-how, with a entire dialogue of the historical past of inhalers in addition to a dialogue on present learn and development.

Part one discusses the basics and improvement of inhaler units in addition to drug formulations for inhalers. The therapy of bronchial asthma is usually mentioned. half experiences contemporary advancements in drug formula and nanotechnology for inhaler units, rising inhaler expertise and attainable destiny trends.

Inhaler units: basics, layout and drug supply is a vital layout advisor for strong commercial perform, and may be a useful source for these gaining knowledge of and treating stipulations equivalent to bronchial asthma; and people constructing and production inhalation devices.

  • Introduces the basics of inhaler technology
  • Discusses the background of inhalers in addition to present examine and improvement in addition to attainable destiny trends
  • Considers the advance of inhaler units, drug formulations and discusses the remedy of asthma

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Extra resources for Inhaler Devices. Fundamentals, Design and Drug Delivery

Sample text

Virchow, J. , et al. 2011. Device type and realworld effectiveness of asthma combination therapy: an observational study. Respiratory Medicine, 105, 1457–1466. Rubin, K. B. and Fink, J. B. 2005. Optimising aerosol delivery by pressurised metereddose inhalers. Respiratory Care, 50, 1191–1200. Smaldone, G. C. 2005. Assessing new technologies: patient–device interactions and deposition. Respiratory Care, 50, 1151–1160. Smith, J. and Tiner, R. Aerosol drug delivery: developments in device design and clinical use.

Nano- and component level scale friction of rubber seals in dispensing devices, Wear, 2010; 268: 845–852. © Woodhead Publishing Limited, 2013 36 Inhaler devices 8. Prokopovich P. A dimensionless analysis of the effect of material and surface properties on adhesion. Applications to medical device design. 1007/978–3-642–28974-3_11. 9. Prokopovich P. and Starov V. Adhesion models: from single asperity to multiasperities contact interactions. An invited review paper to Advances in Colloid and Interface Science, 2011, 168(1–2): 210–222.

For example, the use of HFA imposes certain limitations on the type of sealing materials that can be used in the valve of the inhaler device. The seal is made of an elastomeric material that is placed around a moving stem to maintain the formulation within a chamber. The porosity of the elastomeric sealing material is a key parameter in determining its suitability, since HFA penetration into the material leads to the seal swelling and to poor tribological performance of the device. 3 During the operation of the inhaler device, interacting components are subjected to friction and, consequently, deformation of the sealing material, potentially leading to valve leakage.

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