High-throughput synthesis: principles and practices by Irving Sucholeiki

By Irving Sucholeiki

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W. J. Org. Chem. 1966, 31, 1658–1659. 73. K. J. Am. Chem. , 1975, 97, 1575–1579. 74. -S. J. Org. Chem. 1976, 41, 3258–3261. 75. A. Tetrahedron Lett. 1982, 23, 4439–4442. 76. ; Ajayaghosh, A. Ind. J. Chem. 1988, 27B, 1004–1008. 77. ; Solas, D. Science 1991, 251, 767–773. 78. G. J. Org. Chem. 1995, 60, 2318–2319. 79. ; Tetrahedron Lett. 1994, 35, 7307–7310. 80. , Sucholeiki, I. J. Org. , 1995, 60, 523–528. 81. A. J. Org. Chem. 1995, 60, 6006–6007. 82. W. J. Org. Chem. 1998, 63, 4518–4521. 83. L. D.

These methods were used to rapidly generate hundreds to millions of small to medium-size peptides for identifying novel leads or to help elucidate the chemical basis of known ligand-ligate interactions. Key issues differentiating the various approaches were the size of the libraries, whether they were generated as single compounds or mixtures, and whether the final libraries were tested attached to a solid support or in solution. In the methods affording single compounds, the active member was identified by its physical location.

1 equivalent of DMAP at room temperature. The suspension was then agitated gently overnight. After 24 h, the resulting Fmoc–amino acid–coupled supports 3a and 3b were filtered using a fritted funnel and manually washed with DMF, methanol, and methylene chloride, in that order. The coupled paramagnetic support 3c was not recovered by filtration; instead, the support was separated from the reaction solution using a magnet and the solution aspirated off. The DMF, methanol, and methylene chloride washes were done again using a magnet to attract the support and aspiration to take out the washes (see Chapter 11 for more details).

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