Fish Oil and Vascular Disease by J. Dyerberg (auth.), R. De Caterina, S. D. Kristensen, E. B.

By J. Dyerberg (auth.), R. De Caterina, S. D. Kristensen, E. B. Schmidt (eds.)

Fish Oil and Vascular Disease covers the main appropriate features of fish oil (n-3 polyunsaturated fatty acids) on vascular ailment. The textual content contains heritage epidemiological info, dietary points, results on a number of organic features, very likely mediating the consequences on atherosclerosis and its scientific sequelae, and provides an in depth assurance of the consequences upon blood strain. The ebook is split into 3 major sections. the 1st bargains with the epidemiological and dietary heritage of the n-3 PUFA and their relation to cardiovascular disease.

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6 Finally, it is possible that n-3 fatty acids may have a direct effect on cardiac myocytes. In fact, alteration in the content of cardiac membrane phospholipids has important consequences for ionic transport responsible for cellular excitability, on receptor responsiveness, for the susceptibility to peroxidation during ischaemia and reperfusion, and for electrical stability. 7•8 All these factors may potentially reduce cardiac susceptibility to malignant ventricular arrhytmias. ,.... ;;;6 :::..

C i "iii ,.... 100 u. 0 "iii ,.... 20 u. 0 Q) Q) 0.. a... OS 30 r------1 0.. a... 6 Basal AA L__NS__j L__ NS __j cO 10 ~ cb 0 Basal L Saphenous vein luminal surface Saphenous vein NS r------1 ~ 30 c «i "E. 01 C\J E ~ c i 0.. :: 0 2 a... 01__j L__ L Fig . 2. 8 g DHA/day for 28 days)(white columns). Results are expressed as mean ± SEM. A clear increase in prostacyclin production is evident in all conditions from patients after fish oil treatment (reprinted from Circulation,5 with permission) . equivalent to what is obtainable in platelets from serum thromboxane measurements.

Age and sex 9. Coagulation/fibrinolysis: AT-III? J t-PA/PAI? Fibrinogen? 33 Table II. Cellular processes, n-3 fatty acids and coronary heart disease. 1. J Thromboplastin synthesis 2. J Thromboplastin 3. J LA Membrane phospholipids in relation to: a. Ion transport b. Heart rate c. Receptor d. Stability e. Peroxidation Conclusion In summary, n-3 fatty acids are indeed able to modify some of the well-known risk factors for cardiovascular disease (Tab. I) and are able to modulate the cellular response to several atherogenic stimuli (Tab.

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