ELC by Nomiyama H., Yoshie O.

By Nomiyama H., Yoshie O.

ELC (EBIl-ligand chemokine) (Yoshida et al, 1997). sometimes called MIP-3;'i (macrophage inflammatory protein 3beta and Exodus-3, belongs to a singular classification of CC chemokines that's hugely expressed in lymphoid tissues and has chemotactic task for lymphocytes, yet now not for monocytes or granulocytes. ELC in particular binds and signs via CCR7/EBI1/BLR2. The human gene for ELC (SCYAI9) is found on chromosome 9pl3. that's strange in that the majority different CC chemokine genes are mapped on chromosome 17. one other CC chemokine SLC 6Ckine stocks the receptor CCR7 with ELC and has its gene at the similar chromosome as ELC. even if they proportion basically 32% amino acid identity.These findings recommend that ELC and SLC have been derived from a standard ancestor and feature a job in lymphocyte homing into and trafficking inside of lymphoid tissues and the thymus.

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Maybe not. Network TV news broadcasts and national magazines routinely report on famine, f lood, earthquake, and wars in which children are left homeless and seemingly without hope unless someone reaches into both heart and wallet to help in some meaningful way. Cause marketing is specifically about helping people in a meaningful way that will in turn ref lect back favorably on the doer of the good work. CARE, UNICEF, the International Red Cross, and countless others appeal to companies and individuals without concern for borders, viewing their constituents as the community of the world.

Such an organization cannot afford to let a representative of a company that knows less about an issue or cause appear to be in charge. That would look like the kind of sellout that could irreparably harm the organization’s reputation. Yet a company that receives no responsible role beyond providing financing risks the appearance that it knows precious little about the subject with which it would identify itself. Assuming the partnership is a good fit and both the company and the nonprofit organization share a mutual respect, an easy solution is to create a governing board composed of members (of equal rank and status) from both camps.

Consider, for example, the organizational differences that typically result from dissimilar cultures: On the one hand, the business that achieves maximum efficiency through the use of such incentives as benefit plans, bonuses, and stock options and whose workforce is trained to accomplish objectives within a specific time and budget; and on the other hand, a nonprofit organization that may have some paid staff but relies largely on volunteers, whose motivation is rarely linked to compensation and who must be managed very differently.

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