By Oddvar F. Nygaard; Warren K. Sinclair;
This quantity is a precis of the results of publicity to low degrees of ionizing radiation. resources of such radiation comprise nuclear reactors, the office and the house (radon)
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W h e n an o n c o g e n e is e x p r e s s e d at a sufficiently high level the cell b e c o m e s malignant. This can o c c u r either by direct activation of the o n c o g e n e itself, say by being positioned adjacent t o a p r o m o t e r by c h r o m o s o m a l r e a r r a n g e m e n t or viral insertion, or by inactivation of both of the appropriate pair of o n c o g e n e s . 34 DUDLEY T. GOODHEAD T h e model of Moolgavkar (1989) is formulated on the assumption that h u m a n t u m o r s most c o m m o n l y arise by this latter two-stage p r o c e s s of mutation in each of t w o antioncogenes.