Early Gastrointestinal Cancers by Carlos Fernandez-Martos, Angel Guerrero, Bruce Minsky

By Carlos Fernandez-Martos, Angel Guerrero, Bruce Minsky (auth.), Florian Otto, Manfred P. Lutz (eds.)

This fresh leads to melanoma learn quantity comprises nearly all of the invited professional contributions from the 1st St. Gallen EORTC Gastrointestinal melanoma convention, hung on 22-24 March 2012 in St. Gallen, Switzerland. Written through a number of the world’s prime specialists within the box, the amount constitutes a finished replace on contemporary advancements within the imaging, molecular biology, pathology, and multidisciplinary administration of early melanoma of the gastrointestinal tract. the most recent options relating to analysis and therapy are supplied, and components of consensus and controversy, pointed out. whereas the central concentration is on esophageal and gastric melanoma, advances within the remedy of colorectal and pancreatic melanoma also are mentioned in a few aspect. This publication should be of curiosity to each clinician fascinated about the care of sufferers with gastrointestinal malignancies.​

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Furthermore, the percentage of patients undergoing curative hepatic resection after downsizing of initially unresectable liver metastases was comparable between both treatment strategies (Stillwell et al. 2010). 2 to 22 % in the chemotherapy groups. 8 %). Quantitative analysis of these studies showed that there was no difference in likelihood of curative hepatic resection. 3 Patients Presenting with Resectable Synchronous Liver Metastases and Rectal Cancer For patients with rectal cancer and (potentially) resectable metastases confined to the liver, resection of all malignant lesions with the intention of cure is the principal treatment target.

In these patients, a decision has to be made on whether the primary tumor has to be resected or whether chemotherapy can be started with the primary tumor still in situ. In the following sections, these treatments dilemmas will be further discussed. 2 Patients with Asymptomatic Cancer of the Colon and Unresectable Synchronous Liver Metastases For most patients with stage IV colorectal cancer and unresectable colorectal liver metastases, the principal goal of treatment is palliation in terms of prolonged survival and quality of life (Millikan et al.

2009; Swellengrebel et al. 2011), which can compromise the delivery of postoperative adjuvant chemotherapy. There are also significant late effects from pelvic radiotherapy (Peeters et al. 2005; Lange et al. 2007) and a risk of second malignancies (Birgisson et al. 2005; van Gijn et al. 2011). If preoperative radiotherapy does not impact on survival, can it be omitted in selected cases? The answer is yes—with the proviso that we are using good quality magnetic resonance imaging and good quality TME surgery within the mesorectal plane and the predicted risk of subsequent metastatic disease justifies its use.

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