Drug Targeting: Strategies, Principles, and Applications by Victor Ghetie, Ellen S. Vitetta (auth.), G. E. Francis,

By Victor Ghetie, Ellen S. Vitetta (auth.), G. E. Francis, Cristina Delgado (eds.)

In Drug focusing on: innovations, equipment, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an exceptional selection of modern protocols for drug concentrating on experiences. as well as supplying unique step by step directions, the hugely skilled authors evaluation the vital present focusing on concepts, talk about find out how to construct the constructs, research theoretical issues suitable to good tumors, and describe experimental and scientific purposes of distinctive drug supply structures. additionally provided are new chemical and organic techniques to the instruction of special biopharmaceuticals, together with ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. functions contain the concentrating on of myocardial infarctions utilizing liposomal structures, using monoclonal antibodies to focus on malaria and HIV-infected cells, the focusing on of fusion proteins to leukemias and lymphomas, using antioxidant enzyme-antibody conjugates to focus on the pulmonary endothelium, in addition to tools addressing either the lively and passive concentrating on of tumors.
accomplished and leading edge, Drug focusing on: recommendations, equipment, and Protocols records in functional aspect the foremost new chemical and organic concentrating on tools now getting used to supply latest rising wealthy array of novel diagnostic brokers and promising biopharmaceuticals.

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Commun. 80, 849–857. 43. Ghetie, M. , Uhr, J. , and Vitetta, E. S. (1990) Disseminated or localized growth of a human B-cell tumor (Daudi) in SCID mice. Int. Cancer 45, 481–485. 44. Ghetie, M. , Uhr, J. , and Vitetta, E. S. (1991) Antitumor activity of Fab' and IgG-anti-CD22 immunotoxins in disseminated human B lymphomas grown in mice with severe combined immunodeficiency disease: effect on tumor cells in extranodal sites. Cancer Res. 51, 5876–5880. 45. Ghetie, M. , Uhr, J. , and Vitetta, E. S.

And Pastan, I. (1987) Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. Cell 48, 129–136. Kreitman, R. , Hansen, H. , Jones, A. , FitzGerald, D. J. , Goldenberg, D. , and Pastan, I. (1993) Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice. Cancer Res. 53, 819–825. , FitzGerald, D. J. (1996) Characterization of RFB4— Pseudomonas exotoxin A immunotoxins targeted to CD22 on B-cell malignancies.

173(3), 723–737. 12. Brinkley, M. A. (1992) A survey of methods for preparing protein conjugates with dyes, haptens and crosslinking reagents. Bioconjug. Chem. 3, 2–13. 13. Thorpe, P. , Wallace, P. , Knowles, P. , Relf, M. , Brown, A. N. , Watson, G. , et al. (1988) Improved anti-tumor effects of immunotoxins prepared with deglycosylated ricin A chain and hindered disulfide linkages. Cancer Res. 48, 6396–6403. 24 Ghetie and Vitetta 14. , Batra, J. , and Pastan, I. (1990) Antitumor activity of a thioether-linked immunotoxin: OVB3-PE.

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