Ciba Foundation Symposium 109 - Mucus and Mucosa

Content:
Chapter 1 advent (pages 1–3): A. Silberberg
Chapter 2 legislation of Secretion from Serous and Mucous Cells within the Trachea (pages 4–19): C.B. Basbaum
Chapter three rules of Intestinal Goblet Cells in situ, in Mucosal Explants and within the remoted Epithelium (pages 20–39): Marian R. Neutra, Teresa L. Phillips and Thomas E. Phillips
Chapter four Airway Mucus: Composition and law of its Secretion through Neuropeptides in vitro (pages 40–60): Stephen J. Coles, okay. R. Bhaskar, Donna Defeudis O'Sullivan, Kenneth H. Neill and Lynne M. Reid
Chapter five Acute and persistent versions for Hypersecretion of Intestinal Mucin (pages 61–71): J. Forstner, N. Roomi, R. Fahim, G. Gall, M. Perdue and G. Forstner
Chapter 6 Proteinases free up Mucin from airlines Goblet Cells (pages 72–93): Thomas F. Boat, Pi Wan Cheng, Jeffrey D. Klinger, Carole M. Liedtketi and Bernard Tandler
Chapter 7 a few features of Duodenal Etithelium (pages 94–108): Gunnar Flemstrom and Andrew Garner
Chapter eight Fluid delivery throughout Airway Epithelia (pages 109–120): J. H. Widdicombe
Chapter nine a few Non?Mucin parts of Mucus and their attainable organic Roles (pages 121–136): John R. Clamp and J. Michael Creeth
Chapter 10 Mucus Glycoprotein constitution, Gel Formation and Gastrointestinal Mucus functionality (pages 137–156): Adrian Allen, David A. Hutton, Jeffrey P. Pearson and Lynda A. Sellers
Chapter eleven Macromolecular homes and Polymeric constitution of Mucus Glycoproteins (pages 157–172): Ingemar Carlstedt and John okay. Sheehan
Chapter 12 results of the Anti?Oestrogens, Clomiphene and Tamoxifen, at the Cervical think about woman Infertility (pages 173–179): Max Elstein and Gillian M. Fawcett
Chapter thirteen Terminal Glycosylation in Human Cervical Mucin (pages 180–195): E. N. Chantler and P. R. Scudder
Chapter 14 Comparative stories of Mucus and Mucin Physicochemistry (pages 196–211): Mitchell Litt
Chapter 15 Hydration Kinetics of Exocytosed Mucins in Cultured Secretory Cells of the Rabbit Trachea: a brand new version (pages 212–234): Pedro Verdugo
Chapter sixteen final comments (pages 235–236): A. Silberberg

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Extra resources for Ciba Foundation Symposium 109 - Mucus and Mucosa

Example text

In efforts to identify agents that could potentially interact with goblet cell basolateral membranes to evoke a mucin secretory response, we have considered and tested a variety of neurotransmitters, peptide hormones and mediators of inflammation as candidate secretagogues. Of these, only acetylcholine and cholinomimetic drugs have been shown consistently to function as goblet cell secretagogues in normal intestinal tissue. Using a morphological/autoradiographic assay on rabbit mucosal biopsies in organ culture, we found a-adrenergic and p-adrenergic neurotransmitters and eight intestinal peptide hormones to be without effect on goblet cells (Neutra et a1 1982).

Neutra: The cell is always limited by plasma membrane. T h e ‘empty cup’ shape seems t o be maintained by the cytoskeleton. Boat: Is there evidence that goblet cells in the respiratory tract empty in the same way, maintaining their structure without collapsing? Secondly, is there any stimulus for compound exocytosis in the newborn? A r e newborns compromised in their ability to secrete mucus into the intestinal tract? Neutru: Goblet cells in the respiratory tract are located in the surface epithelium and are not responsive to neurohumoral secretagogues.

2). 22 NEUTRAETAL FIG. 2. A crypt in a mucosal explant (as in Fig. l ) , exposed in vitro to 20pM-carbachol for 30min. During the secretory response central mucin granules are released first, followed by peripheral granules. Factors that accelerate mucus secretion There is evidence that exposure of the mucosal surface to cholera toxin (Forstner et a1 1981, Yardley et al 1972) and to certain macromolecular mediators of the immune response (Lake et a1 1980) results in rapid mucin release from goblet cells.

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