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Extra resources for Biothermodynamics, Part C
The Binding Equation and Its Relationship to Binding Measurements In combining partners in a binding measurement, a major goal is to determine the equilibrium constant or how tightly two partners bind. Continuing with the theme of using fluorescence to monitor the binding, one of the partners, for example, the protein is placed in a cuvette and the fluorescence is monitored upon each addition of a binding partner or ligand to the protein solution. The chemical expression that describes the binding process is P þ L Ð PL ð1:1Þ As the ligand concentration increases, the reaction is driven to the right or toward complex formation.
Thiol Redox Transitions in Cell Signaling, Part A Chemistry and Biochemistry of Low Molecular Weight and Protein Thiols Edited by ENRIQUE CADENAS AND LESTER PACKER VOLUME 474. Thiol Redox Transitions in Cell Signaling, Part B Cellular Localization and Signaling Edited by ENRIQUE CADENAS AND LESTER PACKER VOLUME 475. Single Molecule Tools, Part B: Super-Resolution, Particle Tracking, Multiparameter, and Force Based Methods Edited by NILS G. WALTER VOLUME 476. Guide to Techniques in Mouse Development, Part A Mice, Embryos, and Cells, 2nd Edition Edited by PAUL M.
The solid line the best-fit curve that is generated using the best-fit parameters obtained from nonlinear regression of the data, again using Eq. 8). 3) Â 10À 7 40,007 (39,904/40,110) 33,385 (33,180/33,590) about the best-fit curve. 1, while not exactly those that were used to simulate the data, are close. The errors or uncertainties shown with the best-fit parameters provide limits on the parameter values. These errors are the inevitable consequence of the uncertainties associated with the measured fluorescence values.