Biological Reactive Intermediates IV: Molecular and Cellular by F. Peter Guengerich, Tsutomu Shimada, Arnaud Bondon, Timothy

By F. Peter Guengerich, Tsutomu Shimada, Arnaud Bondon, Timothy L. Macdonald (auth.), Charlotte M. Witmer, Robert R. Snyder, David J. Jollow, George F. Kalf, James J. Kocsis, I. Glenn Sipes (eds.)

The discovering that chemical substances may be metabolically activated to yield reactive chemical species in a position to covalently binding to mobile macromolecules and the concept those reactions may begin toxicological and carcinogenic occasions motivated a gathering through a small crew of toxicologists on the college of Turku, in Finland, in 1975 (Jollow et al. , 1977). The starting to be curiosity during this box of study resulted in next symposia on the college of Surrey, in England in 1980 (Snyder et al. , 1982), and the collage of Maryland within the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth foreign Symposium on organic Reactive Intermediates was once hosted through the guts for Toxicology on the collage of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over three hundred humans attended. there have been 60 platform displays by way of invited audio system, and ninety six volunteer communications within the kind of posters have been provided. those conferences have grown from a small workforce of scientists operating in heavily comparable components to an incredible foreign sequence of symposia which convene each 5 years to study, and position in context, the newest advances in our figuring out of the formation, destiny and outcomes of organic reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers collage, Piscataway, NJ), David J. Jollow Co­ chairman) (Medical collage, South Carolina, Charleston, SC), 1. Glenn Sipes (Co­ chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

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Sato, K. (1989). Glutathione transferases as markers of preneoplasia and neoplasia. Adv. Cancer Res. 52, 205-255. , and Ketterer, B. ). Glutathione conjugation: mechanisms and biological significance. Academic Press, New York. , and Muramatsu, M. (1985). Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Nucleic Acids Res. 13, 6049-6057. B. (1988). Glutathione S- 38 transferase Ya subunit gene: identification of regulatory elements required for basal level and inducible expression.

Environ. Health. 19, 503-518. R. (1985). Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. Drug Metab. Dispos. 13, 553-559. S. (1988). 2-Bromo- (diglutathion-S-yl)hydroquinone nephrotoxicity: Physiological, biochemical, and electrochemical determinants. Mol. Pharmacol. 34, 492-500. Nachtomi, E. (1970). The metabolism of ethylene dibromide in the rat. The enzymic reaction with glutathione in vitro and in vivo. Biochem. Pharmacol. 19, 28532860. Nash, J. , King, L. , Lock, E. , and Green, T.

These findings provide evidence for an important role of near neutral and acidic GSTs in the control of genotoxic metabolites. Pour acidic GSTs consisting of 6 individual subunits were purified by a newly developed method. Prom their close relationship to the Mu class GSTs, which are very potent in the conjugation of polycyclic aromatic epoxides it is concluded, that they, although minor forms in rat liver, may be of importance in the protection against mutagenic, carcinogenic and cytotoxic metabolites of various xenobiotics.

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