By Linda A. Felton, James W. McGinity
This hugely praised booklet provides an in-depth research of actual and chemical houses and functions of aqueous-based polymeric coatings-covering lined dosage types, movie defects, and polymer characterization. New chapters on plastisizers and their purposes in pharmaceutical coatings, adhesion of polymeric movies to reliable substrates, and the impact of pigments on houses of the polymeric coating structures are integrated during this 3rd version. also, this name offers new fabric on polymer interactions with medicinal drugs and excipients and actual getting older of polymeric motion pictures.
Read Online or Download Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences) PDF
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Extra info for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
An increase in release was observed when stored for three months at 35°C, the profile remaining unchanged between three and six months of storage. The increase in release rate for these coatings could not be explained by loss of plasticizer (Table 9) or changes in film porosity (Table 10). Figures 26 and 27 show the corresponding room temperature and 35°C stability profiles for PPA release using TEC as plasticizer. For beads stored at either condition, the drug-release rate slowed at three months, with a further slight slowing at six months.
Mixture entropy is positive and the Gibbs free energy (G = H−T∆S ) is negative. The solubility parameters for a range of plasticizers and ethylcellulose are given in Table 5. Plasticizers with solubility parameters close to that of the polymer are generally considered to be more miscible. 04 Abbreviations: DBS, dibutyl sebacate; DEP, diethyl phthalate; TEC, triethyl citrate; TBC, tributyl citrate. Pseudolatex Dispersions for Controlled Drug Delivery 21 Figure 18 Plasticizer uptake in aqueous polymer dispersions.
Abbreviation: CAP, cellulose acetate phthalate. 5 pH of Phosphate Buffer Solution Figure 40 Disintegration time of aspirin tablets coated with CAP Pseudolatex or CAP/ solvent coating as a function of pH. Abbreviation: CAP, cellulose acetate phthalate. 42 Carlin et al. 5 12 6–19 4–6 4–6 8–10 8–16 RT 35° RT 35° RT 35° 9 mo 12 mo Abbreviation: CAP, cellulose acetate phthalate. 2 Solution Diethyl Phthalate Propylene Glycol 25 33 43 Percent Plasticizer With Respect To Aquacoat 54 CPD solids Figure 41 Disintegration time of aspirin tablets coated with CAP pseudolatex as a function of plasticizer content.