3D Analysis of the Myocardial Microstructure: Determination by Johanna Maria Ticar

By Johanna Maria Ticar

The grasp thesis of Johanna Maria Ticar unearths high-resolution insights into the myocardial microstructure and illustrates that cardiac muscle fibers are immediately, operating in parallel with one most popular fiber path, even though, deposits akin to fats appear to compromise the standard and compact constitution. moment harmonic iteration imaging mixed with optical tissue clearing is a correct technique for making a choice on the three-d muscle fiber and sheet orientations and for this reason, permits the calculation of fiber rotation during the ventricle wall.

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7: Imaging-setup consisting of a laser (L), the actual confocal microscope (M) and the imaging software (S). , Austria). To enable the SHG inducing of collagen, the OPO was tuned to 880 nm. For the detection of a backscattered second-harmonic signal, a bandpass (BP) 465/170 emission filter in combination with a nondescanned detector in epi-mode (backward detection) was used. 5 mm for deep tissue imaging (Schriefl et al. , 2013). The resulting z-stacks comprised two-dimensional images that were recorded of the previously cleared heart specimen, and each z-stack contains sectional images with a range of vision of 620×620 μm in xy-plane.

The table includes the original position of the samples in the heart (specified by left ventricle (LV), endocardial (end), medial (med) and epicardial (epi)), the depth of the respective heart samples, as well as the computed rotation Φ per depth. The concentration parameter b, the coefficient of determination R2 and the dispersion parameter κ were calculated for each image in the z-stack, the mean values of which are listed in the table for each of the 29 specimen. For better comparison of the rotation among the different samples, the rotation Φ was determined per mm depth for every sample.

In case of isotropic fiber distributions κ is 1/3 (b=0) (Schriefl et al. , 2012). 1 Diffusion tensor imaging The feasibility study performed on a small part of a porcine heart wall led to the following results. 1 depicts the fibers of the porcine heart sample in a variety of views, namely coronal (a), only the coronal plane is visible (b), sagittal (c), and axial (d) plane. 1, MA Institute of Technology, USA). 1: Visualization of a porcine heart sample following DTI, depicted in (a) coronal plane, (b) only the coronal plane is visible, (c) sagittal plane, and (d) axial plane.

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